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By N M Hooper; Humana Press

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Levitan, D. and Greenwald, I. (1995) Facilitation of lin-12 mediated signalling by sel-12, a Caenorrhabditis elegans S182 Alzheimer’s disease gene. Nature 377, 351–354. 67. , Doyle, T. , Lee, M. , Slunt, H. , et al. (1996) Assessment of normal and mutant presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93, 14,940–14,944. The Genetics of Alzheimer’s Disease 41 68. , Bronson, R. , Chen, D. , and Tonegawa, S. (1997) Skeketal and CNS deficits in presenilin-1 deficient mice.

Weisgraber, K. , Dong, L. , et al. (1994) Isoform specific interactions of Apolipoprotein E with microtubule associated protein tau: implications for Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 91, 11183–11186. 34. Huang, D. , Weisgraber, K. , Garner, C. , Saunders, A. , et al. (1994) Isoform-specific interactions of Apolipoprotein-E with the microtubule-associated protein MAP2c — implications for Alzheimer’s-disease. Neurosci. Lett. 182(1), 55–58. 35. Nathan, B. , Sanan, D. , Weisgraber, K.

J. Biol. Chem. 272, 14505–14508. 70. , Olivo, J. , et al. (1997) Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. J. Neurochem. 69, 2432–2440. 71. , Xia, M. , Tanzi, R. , and Hyman, B. T. (1997) Developmental regulation of presenilin mRNA expression parallels notch expression. J. Neuropath. Exp. Neurol. 56, 40–44. 72. Kim, T. , Pettingell, W. , Jung, Y. , Kovacs, D. , and Tanzi, R. E. (1997) Alternative cleavage of Alzheimer’s associated presenilins during apoptosis by caspase-3 family proteases.

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